Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer - PubMed
6 hours ago
- #perioperative management
- #immune checkpoint inhibitors
- #locally advanced rectal cancer
- Clinical trials on immune checkpoint inhibitors (ICIs) for locally advanced rectal cancer (LARC) have increased globally, with China being a leading region.
- The Chinese Society of Colorectal Surgery has developed consensus guidance for perioperative and organ-preserving treatment strategies for LARC.
- The guidance provides standards for ICI indications, medication regimens, efficacy evaluations, and follow-up, focusing on perioperative management and organ-sparing strategies.
- Diagnosis is based on mismatch repair/microsatellite instability detection, emphasizing multidisciplinary team involvement in treatment decisions.
- The consensus offers graded recommendations for preoperative immunotherapy duration, postoperative adjuvant therapy, local resection, and organ preservation strategies.
- Safety management processes for perioperative immunotherapy are detailed to guide healthcare professionals and policymakers.