An integrated approach combining transcriptomics, network pharmacology, and experimental validation are used to investigate the mechanism of Lonicerae Japonicae Flos and Forsythiae Fructus extracts ag
4 hours ago
- #Transcriptomics
- #Herbal Medicine
- #Acute Lung Injury
- Integrated approach used to study Lonicerae Japonicae Flos and Forsythiae Fructus (LF) extracts for acute lung injury (ALI) in chickens.
- LF alleviated LPS-induced ALI by reducing inflammation and oxidative stress, improving lung pathology and edema.
- Key mechanisms involve inhibition of MAPK signaling pathway and regulation of apoptosis.
- Identified luteolin, β-sitosterol, and phillyrin as potential active compounds through UPLC-MS/MS and bioinformatics.
- Provides theoretical basis for using this herbal pair in treating bacterial-induced respiratory diseases in poultry.