Nuclear speckles enable processing of RNA from GC-rich isochores - PubMed
7 hours ago
- #genome evolution
- #RNA splicing
- #biological condensates
- Nuclear speckles are membrane-less organelles involved in post-transcriptional processes.
- Removal of speckle core components SON and SRRM2 downregulates GC-rich genes with short introns, causing inefficient splicing.
- GC-rich isochores and speckles are exclusive to amniotes, with SON's IDRs expanding in vertebrates.
- IDR expansion in vertebrates may have facilitated increased GC content by forming condensates essential for splicing GC-rich architectures.