Interventions to reduce the impact of post-tuberculosis lung disease: a scoping review of the literature - PubMed
4 hours ago
- #lung disease
- #tuberculosis
- #scoping review
- A scoping review identified interventions to reduce post-tuberculosis lung disease (PTLD) impact, covering host-directed therapy, inhaled pharmacotherapy, and others.
- 87 studies included showed limited evidence, mostly with small, uncontrolled designs focused on microbiological cure over PTLD outcomes.
- Some interventions, like corticosteroids, doxycycline, metformin, and bronchodilators, showed potential benefits in radiology or spirometry, but findings were inconsistent.
- Antifungals improved symptoms and biomarkers for chronic pulmonary aspergillosis, while evidence for antibacterial therapy and microbiome links to PTLD was lacking.
- Conclusion highlights sparse, heterogeneous evidence and calls for high-quality studies with standardized, person-centered outcomes for TB survivors.