Identification of a putative progenitor-like chondrocyte subpopulation in osteoarthritic human cartilage - PubMed
5 hours ago
- #cartilage regeneration
- #single-cell RNA sequencing
- #osteoarthritis
- Identified a progenitor-like chondrocyte (PLC) subpopulation in osteoarthritic (OA) cartilage using single-cell RNA sequencing (scRNA-seq).
- Found 12 distinct chondrocyte clusters, including 7 known and 3 novel subsets, with PLCs accounting for 2-5% of total chondrocytes.
- PLCs exhibited high expression of stemness-associated genes (e.g., RGS5, PDGFRB, THY1, MCAM) and activation of developmental and extracellular matrix organization programs.
- Pseudotime analysis positioned PLCs upstream of differentiated chondrocyte states, suggesting a progenitor-like role.
- Study provides a molecular framework for future research on cartilage regeneration and OA modulation.