Molecular Landscape of Natural Compounds and Tailored Signaling Pathways in the Battle Against Breast Cancer - PubMed
2 days ago
- #breast cancer
- #signaling pathways
- #phytochemicals
- Breast cancer is the most common disease among women globally, posing significant treatment challenges.
- Current treatments face issues like multidrug resistance and adverse side effects, necessitating new therapeutic approaches.
- About 70% of anticancer drugs are derived from plants, targeting key signaling pathways in breast cancer.
- Phytochemicals modulate pathways such as PI3K/Akt/mTOR, Wnt/β-catenin, Hedgehog, JAK-STAT, and NF-κB to combat cancer.
- Natural compounds suppress breast cancer progression through synergistic effects, as shown in in vitro and in vivo studies.
- Novel delivery methods like lipid carriers, micelles, liposomes, and nanoparticles enhance bioavailability of phytochemicals.
- Further research is needed to fully understand the efficacy of these natural compounds in breast cancer treatment.