Dual Targeting of FAP-Directed Nanoparticles and FRα-Specific CAR-T Cells Induces Additive Anti-Tumor Effects in Triple-Negative Breast Cancer - PubMed
3 days ago
- #Triple-negative breast cancer
- #CAR-T cell therapy
- #Nanoparticles
- Dual targeting of FAP-directed nanoparticles and FRα-specific CAR-T cells enhances anti-tumor effects in triple-negative breast cancer (TNBC).
- TNBC lacks hormone receptors and HER2, making treatment challenging.
- Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) hinder CAR-T cell therapy.
- Anti-FAP@OMF-NPs target CAFs, while FRα-specific CAR-T cells target TNBC cells.
- Combined treatment significantly improves destruction of TNBC-CAF heterospheroids compared to monotherapies.
- The combination increases secretion of immune-activating cytokines (IFN-γ, granzyme A, granzyme B).
- This dual-targeting approach offers a promising strategy to overcome TME-mediated immunosuppression in TNBC.