Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia - PubMed
6 hours ago
- #osteosarcopenia
- #DUSP4/p38 MAPK
- #nanovesicles
- Osteosarcopenia (OSP) is a degenerative syndrome combining osteoporosis and sarcopenia, with high global prevalence due to aging and disuse.
- The p38 MAPK pathway plays a key role in musculoskeletal degeneration, and DUSP4 inhibits this pathway.
- Targeted delivery of microRNAs (e.g., miR-206-5p) that inhibit DUSP4 can activate p38 MAPK, promoting osteogenic and myogenic differentiation.
- A hybrid nanovesicle (miR@DT/iMNV) was engineered for dual-targeted delivery to bone and muscle, combining peptide-modified liposomes and iPSC-derived MSC-EVs.
- miR@DT/iMNV enhances stem cell differentiation, modulates macrophages, restores mitochondrial function, and improves bone/muscle mass in a murine OSP model.
- This approach offers a novel therapeutic strategy for OSP, addressing both bone and muscle regeneration.