Deficient extravillous trophoblast invasion caused by impaired sialylation-Siglec-7 interaction contributes to recurrent pregnancy loss - PubMed
6 hours ago
- #recurrent pregnancy loss
- #trophoblast invasion
- #sialylation
- Deficient extravillous trophoblast (EVT) invasion due to impaired sialylation-Siglec-7 interaction contributes to recurrent pregnancy loss (RPL).
- EVTs from RPL patients show reduced sialylation and increased Siglec-7+ decidual natural killer (dNK) cells.
- Sialylated glycoproteins on EVTs engage Siglec-7 on dNK cells, stimulating IL-8 secretion, which activates STAT3 in EVTs to enhance migration and invasion.
- Restoration of EVT sialylation rescues IL-8-STAT3 signaling and invasive capacity, suggesting a therapeutic strategy for RPL.
- The study identifies a critical sialic acid-Siglec-7-IL-8-STAT3 signaling axis essential for EVT invasion and healthy pregnancy outcomes.