Cancer Surveillance in Lynch Syndrome: A Scoping Review of International and National Guidelines - PubMed
2 hours ago
- #Lynch Syndrome
- #Cancer Surveillance
- #Clinical Guidelines
- Colonoscopy is universally endorsed for Lynch syndrome surveillance, with initiation ages ranging from 20-35 years and intervals from 1-3 years, depending on MMR gene status.
- Recommendations for extracolonic surveillance vary significantly; most guidelines support endometrial biopsy and consideration of prophylactic hysterectomy with bilateral salpingo-oophorectomy after childbearing.
- Gastric, pancreatic, urothelial, and other screening strategies are inconsistently endorsed, often limited to high-risk subgroups, while aspirin chemoprevention is widely supported despite dose variability.