Synthetic circuits for cell ratio control - PubMed
5 hours ago
- #synthetic biology
- #genetic engineering
- #cell differentiation
- Introduction of recombinase-mediated genetic devices for precise control of cell population ratios.
- Development of data-driven models to predict binary differentiation outcomes accurately.
- Construction of parallel and series circuit topologies for multistep cell-fate branching programs.
- Application in precision fermentation consortia for optimized cell-type ratios in pigmentation and cellulose degradation.
- Extension of technology to mammalian cells and engineering of multicellular aggregates with genetically encoded morphologies.
- Comprehensive characterization of recombinase-based cell-fate branching mechanisms.
- Patent application preparation by some authors, indicating potential commercialization of the technology.