Real or Not Real? An Elevated TSH - PubMed
5 hours ago
- #Macro-TSH
- #Thyroid Function Tests
- #Immunoassay Interference
- A 19-year-old male presented with mild fatigue and chronic constipation.
- Lab results showed elevated TSH (85 mIU/L) but normal free thyroxine and total triiodothyronine.
- Diagnosis of Macro-TSH was confirmed via TSH antibody testing and gel filtration chromatography.
- Macro-TSH is rare and can mimic hypothyroidism, requiring further evaluation when TSH results don't match clinical presentation.
- Testing options include commercially available TSH antibody tests or gold-standard gel filtration chromatography (not commercially available).
- Case highlights the importance of investigating incompatible thyroid function test results to avoid misdiagnosis.