High-dimensional single-cell analyses reveal neutrophil heterogeneity in guttate psoriasis - PubMed
11 hours ago
- #Guttate psoriasis
- #Neutrophil heterogeneity
- #Group A Streptococcus
- High-dimensional single-cell analyses reveal neutrophil heterogeneity in guttate psoriasis (GP).
- GP is associated with streptococcal throat infection, and neutrophils are the first immune cells to respond to Group A Streptococcal (GAS) infection.
- The study focuses on phenotyping neutrophils in GP skin and understanding their role in disease pathogenesis.
- Immature neutrophil subsets in GP skin exhibit antigen processing and presentation signatures, similar to those in healthy controls only upon GAS stimulation.
- GAS-induced HLA-DR+ neutrophils induce CD4+ T cell proliferation, suggesting a role in disease pathogenesis.
- Other neutrophil subsets in GP are linked to migration, neutrophil extracellular trap formation, and phagocytosis.
- Funding sources include various Swedish foundations and research councils.