Inhaled Antibiotics to Treat Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis - PubMed
5 hours ago
- #ventilator-associated pneumonia
- #inhaled antibiotics
- #meta-analysis
- Inhaled antibiotics significantly improve clinical cure and reduce all-cause mortality in ventilator-associated pneumonia (VAP) patients.
- Benefits of inhaled antibiotics are more pronounced in VAP-only populations compared to mixed pneumonia groups.
- Inhaled antibiotics enhance microbiological eradication and reduce the emergence of new drug resistance.
- Compared to IV antibiotics, inhaled antibiotics shorten ventilator duration and lower nephrotoxicity risks.
- The study suggests the need for further high-quality trials to confirm the advantages of inhaled antibiotics over IV therapy.