β-Arrestins and disease-linked variants: opportunities for targeted modulation - PubMed
12 hours ago
- #β-arrestin
- #GPCR
- #drug discovery
- β-Arrestins play crucial roles in GPCR desensitization, trafficking, and signaling but remain underexplored as drug targets.
- Recent advances in small-molecule and peptide design enable direct modulation of β-arrestins, offering new therapeutic opportunities.
- Disease-associated mutations in β-arrestins highlight potential for mutation-specific targeting in precision drug development.
- The review covers β-arrestin biology, disease-linked mutations, and emerging strategies for developing arrestin-targeting compounds, especially peptides.