Neuroinflammation as a result of non-neurotropic herpesvirus infection - PubMed
6 hours ago
- #Multiple sclerosis
- #Neuroinflammation
- #Epstein-Barr virus
- The non-neurotropic Epstein-Barr virus (EBV) is suggested to initiate the prodromal phase of multiple sclerosis (MS) long before clinical symptoms appear.
- This review discusses mechanisms by which EBV may cause neuroinflammatory B-cell migration to the central nervous system (CNS), as seen in primary CNS lymphomas and MS.
- It summarizes mechanisms of molecular mimicry and autoreactive B-cell expansion driven by EBV.
- Approaches to target EBV-mediated neuroinflammation for therapeutic interventions in people with MS are explored.
- Recent insights into EBV's association with MS provide exciting understanding of autoimmune disease initiation, and successful therapies may confirm EBV's role in the clinical phase of MS.