ABHD2 activity is not required for the non-genomic action of progesterone on human sperm - PubMed
4 hours ago
- #ABHD2
- #Progesterone
- #CatSper
- The study investigates whether ABHD2 is necessary for progesterone-induced CatSper channel activation and motility responses in human sperm, concluding it is not required.
- Potent ABHD2 inhibitors were synthesized and used to test the enzyme's role, showing no effect on calcium influx or hyperactivated motility when inhibited.
- Findings indicate that progesterone does not activate ABHD2, and its hydrolase activity is not involved in the non-genomic progesterone effects on sperm.
- Limitations include the possibility of ABHD2 having a structural role independent of enzymatic activity within a protein complex.
- The research is funded by the Gates Foundation and German organizations, with authors noting no competing interests affecting the conclusions.