Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney fibrosis via the L-carnitine-SIRT3 axis - PubMed
5 hours ago
- #Mitochondrial Metabolism
- #Hyperoside
- #Kidney Fibrosis
- Hyperoside reduces renal fibrosis and mitochondrial injury in folic acid-induced nephropathy and unilateral ureteral obstruction mouse models.
- It directly binds and stabilizes ACAT1, inhibiting ubiquitination to enhance its enzymatic activity and protein stability.
- This promotes L-carnitine-dependent metabolic flux, activating SIRT3, which reduces reactive oxygen species and enhances mitophagy.
- ACAT1 knockdown reverses hyperoside's benefits, while L-carnitine can partially restore them, confirming the pathway's importance.