Repurposing T-type calcium channel blocker Lomerizine as a therapeutic strategy for glioblastoma - PubMed
5 hours ago
- #drug-repurposing
- #glioblastoma
- #lomerizine
- Glioblastoma (GBM) is a highly malignant primary brain tumor with treatment resistance due to glioma stem/initiating cells (GICs).
- Drug repositioning screening identified lomerizine, a T-type calcium channel blocker used for migraines, as a potential GBM treatment.
- Lomerizine inhibited proliferation, migration, invasion, and cell cycle progression while inducing apoptosis in GICs and differentiated glioma cells.
- The drug inactivated STAT3, dephosphorylated AKT and ERK in GICs, and showed strong tumor-suppressive effects.
- In vivo, lomerizine reduced tumor volume and prolonged survival, indicating potential as a novel GBM therapeutic agent.