Aging Impairs Macrophage Phagocytosis Through Mitochondrial ROS-Induced Collagen Production - PubMed
4 hours ago
- #Mitochondrial ROS
- #Macrophage Phagocytosis
- #Aging
- Aging reduces phagocytic activity in macrophages from both humans and mice.
- Aged macrophages show increased expression of collagen genes, particularly COL1A1, which impairs phagocytosis by binding to actin filaments and inhibiting F-actin turnover.
- Mitochondrial ROS drives collagen overproduction in aged macrophages, and MitoTEMPO treatment restores phagocytosis by improving actin dynamics.
- In a mouse model, MitoTEMPO enhanced bacterial phagocytosis by peritoneal macrophages, suggesting mitochondrial redox balance and collagen as targets for healthy immune aging.