Reduced podocyte stiffness is a feature of proteinuric kidney disease - PubMed
5 hours ago
- #podocyte
- #proteinuria
- #kidney-disease
- Reduced podocyte stiffness is a common feature in proteinuric kidney diseases.
- Study used in situ atomic force microscopy on murine models and human biopsies to analyze stiffness changes in glomeruli, podocytes, and glomerular basement membranes.
- Podocyte softening occurs even when podocytes are on a thickened and stiffer glomerular basement membrane.
- Lower levels of beta1 integrin, critical for podocyte adhesion, were found in proteinuric conditions.
- Beta1 integrin inhibition leads to podocyte softening and inactivation of mechanosensitive transcription co-factors YAP and TAZ.
- YAP/TAZ inhibition results in reduced beta1 integrin expression, affecting podocyte health.
- Glomeruli and their components show divergent stiffness changes in response to different injuries.