PICALM Genetic Variant Alters mRNA Expression Without Affecting Protein Levels or Tau Spreading in Alzheimer's Disease - PubMed
3 months ago
- #Alzheimer's disease
- #tau pathology
- #PICALM
- PICALM is a significant genetic susceptibility locus for late-onset Alzheimer's disease (AD).
- The protective rs3851179T allele reduces PICALM mRNA levels compared to the non-protective rs3851179C allele.
- PICALM protein levels are reduced in AD brains, but this reduction does not affect tau propagation.
- The study found no significant difference in tau accumulation between wild-type and Picalm+/- mice.
- The AD susceptibility linked to PICALM variants likely involves mechanisms other than tau spread, possibly related to autophagy, endocytic, or vascular function.