From clinical practice to mechanistic insights in ketogenic diets for epilepsy - PubMed
5 hours ago
- #seizure-control
- #ketogenic-diet
- #epilepsy
- Ketogenic diet therapies (classic ketogenic diet, modified Atkins diet, low glycaemic index treatment) help control seizures by shifting metabolism from glucose to ketone bodies.
- These diets improve mitochondrial function, reduce neuroinflammation, and modulate neurotransmitters.
- Ketogenic diets influence the gut microbiome, potentially aiding seizure control through neurotransmitter balance.
- The classic ketogenic diet is effective but restrictive, while modified Atkins and low glycaemic index diets offer more flexibility and tolerability.
- Evidence from randomized controlled trials on ketogenic diets is limited, per Cochrane reviews and meta-analyses.
- Early initiation of ketogenic diets, especially in children or metabolic epilepsies, improves seizure outcomes and may prevent mitochondrial/neuronal damage.
- More research is needed to address efficacy and real-world challenges, considering factors like age, epilepsy type, and care delivery contexts.