Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease - PubMed
5 hours ago
- #oral-gut axis
- #systemic disease
- #microbiome dysbiosis
- The oral-gut axis is a bidirectional pathway connecting oral microbiota to systemic health.
- Dysbiosis of the oral microbiome, caused by pathogens like Porphyromonas gingivalis and Fusobacterium nucleatum, disrupts gut ecology.
- Disruption mechanisms include direct translocation, metabolite signaling (e.g., TMAO, SCFAs), and immune crosstalk (e.g., Th17).
- This leads to gut barrier dysfunction, systemic inflammation, and metabolic disturbances.
- Linked systemic diseases include rheumatoid arthritis, cardiovascular diseases, neurodegenerative disorders, metabolic syndrome, and gastrointestinal cancers.
- Oral pathogens are emerging as biomarkers for non-invasive disease detection.
- Therapeutic strategies include probiotics, dietary interventions, and periodontal therapy to restore microbial homeostasis.
- Future research should focus on longitudinal human studies and multi-omics approaches for better mechanistic understanding.