Treatable traits in interstitial lung disease: towards precision medicine - PubMed
21 hours ago
- #Treatable Traits
- #Precision Medicine
- #Interstitial Lung Disease
- Current ILD pharmacotherapies include systemic glucocorticoids, steroid-sparing immunosuppressants, and antifibrotic drugs, each targeting major biological components.
- Treatment is based on a treatable traits approach, integrating clinical, lab, radiological, and pathological features to match biology with medication strategy.
- Acute inflammatory presentations typically receive systemic glucocorticoids; chronic inflammatory disease gets long-term steroid-sparing immunosuppression; progressive fibrotic disease receives antifibrotics.
- Emerging therapies like nerandomilast (a PDE4B inhibitor with antifibrotic/immunomodulatory effects) are being introduced, approved recently in the USA.
- Future goals include integrating molecular endotypes to enable precision-based ILD management, addressing knowledge gaps in current approaches.