Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition - PubMed
6 hours ago
- #immunotherapy
- #CAR-T cells
- #cellobiose
- Fungal-derived cellobiose metabolic pathway helps T cells bypass glucose competition in tumors.
- Engineered T cells with fungal proteins can import and hydrolyze cellobiose into glucose.
- Cellobiose supplementation restores T-cell functions like viability, proliferation, and cytotoxicity under glucose deprivation.
- Modified T cells (including CAR-T cells) show improved tumor suppression and prolonged survival.
- This approach could enhance cancer immunotherapy and study glucose metabolism in various diseases.