X-ray preactivated reversible persistent luminescence enables photodynamic immunotherapy of deep tumors - PubMed
5 hours ago
- #persistent luminescence
- #immunotherapy
- #photodynamic therapy
- Persistent luminescence is a promising approach for photodynamic therapy (PDT) in deep-seated tumors.
- X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles (ETPNs) feature reversible 'on-off' afterglow properties.
- X-ray-activated porous NaYF4:Er@NaGdF4 nanoparticles enable continuous activation of chlorin e6 (Ce6) to generate reactive oxygen species (ROS), causing DNA damage.
- Elimusertib enhances ROS-induced DNA damage and activates the cGAS-STING pathway, improving immuno-photodynamic therapy efficacy.
- All in vivo experiments were conducted using female mice.
- ETPNs offer a robust and controllable platform for combined immuno-photodynamic therapy of deep-seated tumors.