The rise of bone marrow organoids as next-generation models for blood formation and failure - PubMed
6 hours ago
- #hematopoietic research
- #bone marrow organoids
- #disease modeling
- Bone marrow organoids (BMOs) are 3D culture models replicating bone marrow niche features.
- BMOs surpass classical models by better mimicking 3D architecture, cellular diversity, and spatial organization.
- They serve as scalable, cost-effective alternatives to animal models, reducing animal experimentation.
- iPSC-derived BMOs enable personalized disease modeling, drug testing, and gene editing for precise studies.
- Recent protocols by Christoph Klein and Abdullah Khan have advanced BMO generation and applications.
- BMOs are used to model inflammatory responses, genetic bone marrow failure syndromes, and multiple myeloma.