The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages - PubMed
5 hours ago
- #type-I interferon
- #trained immunity
- #alveolar macrophages
- Type-I interferon (IFN-I) priming signal balances antibacterial and antitumor trained immunity (TI) in alveolar macrophages (AMs).
- Influenza A virus (IAV) infection induces lasting transcriptional imprints of acute IFN-I signaling in AMs, enhancing both antibacterial and antitumor responses.
- IFN-I signaling is crucial for antitumor TI but limits antibacterial TI in AMs.
- Human AMs with IFN-I signaling transcriptional imprints are linked to immune activation in lung cancer tissues.
- The study highlights IFN-I as a key signal for versatile TI functions in AMs.