Concomitant plasma cell myeloma and chronic myelomonocytic leukemia in elderly: diagnostic complexity, therapeutic challenges - case report and literature review - PubMed
6 days ago
- #CMML
- #plasma cell myeloma
- #hematologic malignancies
- Case report of an 82-year-old female with concomitant plasma cell myeloma and chronic myelomonocytic leukemia (CMML).
- Diagnostic challenges highlighted due to overlapping features of CMML and myeloma.
- Laboratory findings included leukocytosis, monocytosis, anemia, thrombocytopenia, hypercalcemia, and renal dysfunction.
- Bone marrow biopsy showed 20-25% CD138+ plasma cells and features of CMML.
- NRAS and TET2 mutations were detected via next-generation sequencing.
- Treatment involved leukapheresis, hydroxyurea, and bortezomib-dexamethasone, complicated by cytopenias.
- Emphasizes the need for a multidisciplinary approach and personalized therapy in complex hematologic overlap syndromes.