Boron neutron capture therapy (BNCT) for experimental bladder cancer: systemic or intravesical approach - PubMed
5 hours ago
- #bladder cancer
- #BNCT
- #radiotherapy
- BNCT studied in experimental bladder cancer model using systemic or intravesical boronophenylalanine.
- BNCT reduced tumor burden by 15-30%, similar to conventional radiotherapy (cRT).
- Lower incidence of persistent cancer (71.4%) with intravesical BNCT vs. systemic (87.5%) and cRT (100%).
- Intravesical BNCT showed lower proliferative and higher apoptotic indexes compared to cRT.
- Intravesical BNCT resulted in reduced pro-inflammatory TNF-α expression in bladder.
- Intravesical BNCT had fewer adverse inflammatory effects in perivesical tissues like colon and uterus.