Psilocybin or Nicotine Patch for Smoking Cessation: A Pilot Randomized Clinical Trial - PubMed
14 hours ago
- #psilocybin
- #smoking cessation
- #clinical trial
- The study compared psilocybin plus cognitive behavioral therapy (CBT) with nicotine patch plus CBT for smoking cessation.
- Participants were 82 psychiatrically healthy adult smokers, with a mean age of 47.6 years.
- At 6-month follow-up, 40.5% of psilocybin group showed prolonged abstinence vs. 10.0% in nicotine patch group.
- Psilocybin group also had higher 7-day point prevalence abstinence rates (52.4%) compared to nicotine patch (25.0%).
- No serious adverse events were reported for either treatment.
- Psilocybin with CBT showed significantly higher long-term abstinence rates than nicotine patch with CBT.
- The study suggests psilocybin may be a promising treatment for tobacco smoking cessation.