Propranolol enhances the oncolytic effect of newcastle disease virus on canine mammary tumor cell by modulating the IFN-I-mediated JAK-STAT signaling pathway - PubMed
5 hours ago
- #JAK-STAT pathway
- #oncolytic therapy
- #canine mammary tumor
- Propranolol enhances the oncolytic effect of Newcastle disease virus (NDV) on canine mammary tumor (CMT) cells.
- NDV kills tumor cells directly and stimulates antitumor immunity but activates Type I interferon (IFN-I) signaling, which restricts its replication via the JAK-STAT pathway.
- Propranolol suppresses antiviral responses, increasing NDV replication and reducing IFN-I release and JAK-STAT signaling activation in CMT cells.
- In vitro studies showed reduced cell viability, migration, and invasion in CMT-U27 cells when treated with the combination of propranolol and NDV.
- In a CMT-U27 xenograft model, both NDV alone and the combination therapy prolonged survival and suppressed tumor growth, with enhanced NDV replication in the combination group.
- The combination therapy inhibits IFN-I production and the JAK-STAT pathway, leading to increased viral load and enhanced oncolysis.