B cell immunity to the Lassa virus glycoprotein is a correlate of vaccination-induced virus control in mice - PubMed
8 hours ago
- #vaccine correlates
- #Lassa virus
- #B cell immunity
- B cell immunity targeting the Lassa virus glycoprotein correlates with viral load control in vaccinated mice.
- Heterologous cross-reactive glycoproteins from related arenaviruses can induce B cell immunity that suppresses LASV viremia.
- Viral control occurs without CD8 T cells or neutralizing antibodies, linking to non-neutralizing glycoprotein-specific antibodies.
- Activated, somatically hypermutated B cells from cross-reactive responses are sufficient to reduce viral loads upon transfer.
- This study identifies vaccination-induced B cell immunity as a key correlate of protection, independent of pre-challenge neutralizing titers.