LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma - PubMed
2 months ago
- #nasopharyngeal carcinoma
- #lncRNA
- #ferroptosis
- Ferroptosis is an iron-dependent programmed cell death that inhibits tumor progression.
- MICAL2 influences p53 nuclear translocation and facilitates its ubiquitination by recruiting MDM2, leading to p53 degradation.
- This process inhibits ferroptosis in nasopharyngeal carcinoma (NPC) cells, promoting NPC progression and worsening patient prognosis.
- LINC-AC092535.5, a novel lncRNA, regulates MICAL2 mRNA levels at transcriptional and post-transcriptional levels.
- Transcriptome sequencing and RACE experiments helped identify the function of LINC-AC092535.5.
- These findings expand the ferroptosis gene regulatory network and may inform new NPC treatment strategies.