Activity of essential oils against Caenorhabditis elegans: Showing anthelmintic potential for new products - PubMed

7 hours ago

Essential oils from Thymus vulgaris, Eugenia caryophyllus, Cymbopogon flexuosus, Illicium verum, Pelargonium graveolens, and Origanum vulgare were tested for nematicidal activity against Caenorhabditis elegans.
Origanum vulgare showed the highest potency in adult lethality and egg hatching assays, with low LC50 values.
Several essential oils, including Illicium verum and Thymus vulgaris, remained effective against ivermectin and albendazole-resistant strains with low resistance ratios.
Sub-lethal concentrations of five out of six oils significantly inhibited egg-laying in C. elegans.
Scanning electron microscopy revealed cuticular damage, suggesting integumentary disruption as a mechanism of action.
The study highlights the potential of these essential oils, especially Origanum vulgare and Illicium verum, as candidates for new anthelmintic products against drug-resistant nematodes.

Hasty Briefsbeta