Zuogui pill ameliorates DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian ageing through activation of SIRT1 - PubMed
5 hours ago
- #ovarian aging
- #SIRT1
- #DNA damage
- Zuogui Pill (ZGP) delays ovarian aging by enhancing ovarian stem cell (OSC) stemness, increasing follicle count, and raising serum AMH and E2 levels.
- ZGP upregulates SIRT1 to suppress DNA damage (γ-H2AX and CHEK2) and modulate acetylation of Ku70 and p65, reducing p53/p21 expression and SASP.
- The study employs bioinformatics (WGCNA, network pharmacology) and experimental validation in mice and D-gal-induced OSC models to confirm SIRT1-dependent mechanisms.