Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK-STAT signaling - PubMed
3 months ago
- #Metabolic surgery
- #Obesity
- #Diabetic kidney disease
- Metabolic bariatric surgery (MBS), specifically vertical sleeve gastrectomy (VSG), mitigates early kidney injury in obese youth with type 2 diabetes (T2D).
- Post-VSG, improvements included weight loss, better insulin sensitivity, reduced renal hyperfiltration, decreased total kidney volume, and lower microalbuminuria.
- Single-cell RNA sequencing revealed repression of glycolysis, gluconeogenesis, and TCA cycle genes in kidney cells, alongside upregulated AMPK and FOXO3 pathways.
- VSG reduced mTORC1 activity (evidenced by lower pS6K) and diminished JAK-STAT pathway activation in proximal tubule cells.
- Findings suggest potential non-surgical therapeutic targets for obesity- and diabetes-related kidney disease.