Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 - PubMed
5 hours ago
- #protein import
- #cellular stress
- #mitochondria
- Mitochondria adapt to cellular stress to ensure cell survival.
- OMA1, a stress-regulated mitochondrial peptidase, plays a key role in mitochondrial stress responses.
- OMA1 regulates mitochondrial protein import and OXPHOS biogenesis by cleaving the chaperone DNAJC15.
- Loss of DNAJC15 impairs mitochondrial protein import and OXPHOS biogenesis under stress.
- Non-imported mitochondrial preproteins accumulate at the ER, triggering an unfolded protein response.
- The study highlights the interdependence of proteostasis regulation between mitochondria and other organelles.