The Inherited Basis of Coronary Artery Disease - PubMed
4 hours ago
- #genetics
- #polygenic risk score
- #coronary artery disease
- Genetic research has advanced understanding, treatment, and prevention of coronary artery disease (CAD).
- Most current CAD medications target genetic mechanisms promoting atherosclerosis.
- Monogenic causes of CAD affect ~1 in 250 people, often leading to very high lipid levels.
- Hundreds of common genetic variants with small effects influence CAD at the population level.
- Polygenic risk scores (PRS) can show a person's CAD risk relative to the general population.
- People in the top 5% of PRS have 3-5 times higher CAD risk than those with average scores.
- PRS can multiply absolute risk from clinical scores, but clinical integration challenges remain.