Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome - PubMed
5 hours ago
- #Redox signaling
- #NLRP3 inflammasome
- #Cofilin-1
- Cofilin-1 is a redox-sensitive regulator of the NLRP3 inflammasome.
- In resting cells, cofilin-1 binds directly to NLRP3 but dissociates upon oxidation by ROS during activation.
- CAPS-associated mutant NLRP3 shows reduced binding to cofilin-1.
- Residues 101-104 of cofilin-1 are critical for NLRP3 interaction.
- Oxidation-independent peptides containing the NLRP3 binding motif can suppress inflammasome activation.
- Bioinformatic analyses support cofilin-1's role in NLRP3 activation by ROS and potential therapeutic use of cofilin-1-derived peptides.