Exercise Attenuates Aortic Dissection Via PDE5A-Mediated Inhibition of Vascular Smooth Muscle Cell Phenotypic Switch - PubMed
7 hours ago
- #aortic dissection
- #exercise benefits
- #vascular smooth muscle cells
- Exercise helps prevent aortic dissection (AD) by maintaining vascular smooth muscle cell (VSMC) contractility.
- The study identifies PDE5A as a key exercise-responsive gene that is downregulated in AD conditions but upregulated by exercise.
- VSMC-specific overexpression of PDE5A reduces AD progression, while its inhibition negates exercise benefits.
- RUNX1 is identified as a transcriptional repressor of PDE5A, upregulated in AD and suppressed by exercise.
- Inhibition of RUNX1 preserves VSMC contractility and reduces AD incidence, highlighting the RUNX1-PDE5A pathway as a preventive target.