Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification - PubMed
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- #kidney disease
- #patient stratification
- #transcriptomics
- Shared multicellular injury programs in AKI and CKD enable mechanistic patient stratification.
- Single nucleus transcriptomics used on over 150 KPMP participants to study molecular diversity in kidney biopsies.
- Identified two multi-cellular programs linked to acute injury and chronic damage, shared across AKI and CKD patients.
- Programs reflect tissue-level changes in tubular epithelial cells and stress markers in all cell types.
- NFkB, AP-1 complexes, and STAT family identified as potential regulators of acute and chronic programs.
- Molecular measures mapped to urine and plasma protein profiles, predictive of outcomes in UK Biobank cohort.
- Findings support shared molecular mechanisms in AKI and CKD, beyond conventional disease categorization.