Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity - PubMed
6 hours ago
- #Prostate Immunology
- #Tissue-Resident Memory T Cells
- #Spatial Transcriptomics
- A protective and heterogeneous population of long-lived tissue-resident memory CD8+ T cells (Trm) forms in the prostate after acute infection in mice.
- Distinct stromal and glandular epithelial niches in the prostate drive phenotypic and functional diversity in Trm cells, with IL-15 and TGFβ highest in the epithelium, promoting persistence and cytotoxicity.
- Spatial transcriptomics provides a framework showing how localized signals in discrete tissue regions influence T cell fate and differentiation in both mice and humans.