Tryptophan metabolism reprogramming regulates Th1/Th2 immune balance and inhibits mast cell activation - PubMed
6 hours ago
- #Immune regulation
- #Asthma
- #Tryptophan metabolism
- Tryptophan metabolism reprogramming influences Th1/Th2 immune balance and mast cell activation.
- High tryptophan levels promote Th1 differentiation, increasing Notch1/Jagged1, IL-2, and IFN-γ, while reducing IL-4.
- Tryptophan suppresses mast cell activation by reducing tryptase expression and histamine secretion.
- IDO1/TDO inhibitor HY-149,411 affects tryptophan-dependent histamine release, indicating tryptophan catabolism's role in mast cell regulation.
- Findings suggest tryptophan metabolism as a potential therapeutic target for asthma by correcting Th1/Th2 imbalance and reducing allergic inflammation.