Targeted Delivery of GLUT1 Inhibitor via Macrophage Nanovesicles for Pulmonary Arterial Hypertension Therapy - PubMed
3 days ago
- #immunometabolism
- #glycolysis inhibition
- #drug delivery
- Mac@WZB117 is a macrophage membrane-camouflaged nanovesicle delivering GLUT1 inhibitor WZB117 to target M1 macrophages for PAH treatment.
- In mouse PAH models, Mac@WZB117 reversed arterial thickening and collagen deposition, downregulated GLUT1 expression in M1 macrophages, and shifted macrophage polarization from M1 to M2.
- The intervention inhibited glycolysis, lipid metabolism, and TGF-β signaling pathways, reshaping the immuno-metabolic lineage and reorganizing hyperactive M1 macrophages spatially.