Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4 - PubMed
5 hours ago
- #cardiac injury
- #DPP4
- #gut-heart axis
- Cardiac ischemia/reperfusion (I/R) injury is worsened by gut microbiota, specifically Bacteroides acidifaciens.
- B. acidifaciens enrichment occurs due to intestinal hypoxia and high lactate post-I/R, producing microbial DPP4 (BaDPP4).
- BaDPP4 degrades protective peptides like GLP-1 in plasma, increasing myocardial injury.
- Inhibition of BaDPP4 with daurisoline reduces cardiac dysfunction in models.
- Human studies show B. acidifaciens and BaDPP4 levels correlate with cardiac damage markers in acute myocardial infarction patients.
- Findings reveal a gut-heart axis and suggest targeting the hypoxia-lactate-BaDPP4 pathway for cardioprotection.