Dietary palmitic acid inhibits colorectal cancer progression through enhancing bisecting GlcNAc - PubMed
5 hours ago
- #colorectal-cancer
- #glycosylation
- #dietary-fatty-acids
- Dietary palmitic acid (PA) inhibits colorectal cancer (CRC) progression by enhancing bisecting GlcNAc levels.
- Bisecting GlcNAc and MGAT3 levels are decreased in CRC patients, and their downregulation promotes cancer cell proliferation, migration, and invasion while reducing apoptosis.
- A PA-rich diet suppresses CRC carcinogenesis in mice by increasing bisecting GlcNAc modifications, particularly on desmoglein 2 (DSG2).
- Mgat3fl/fl Villin-Cre mice showed abolished inhibitory effects of PA, confirming MGAT3's role in CRC suppression.
- DSG2 inhibits CRC via the EGFR/AKT signaling pathway, linking dietary fatty acids to cancer regulation.