HLA class I signal peptide variation predicts strength of NKG2A+ NK cell response to missing-self and risk of human disease - PubMed
a day ago
- #NK cells
- #disease risk
- #HLA-E
- HLA class I signal peptide variation influences NKG2A+ NK cell response to missing-self and disease risk.
- The SP score quantifies CD94/NKG2A-HLA-E interaction strength based on signal peptide genotype.
- Higher SP scores correlate with stronger NKG2A+CD56bright NK cell response to HLA class I-negative cells.
- Higher SP scores are associated with lower risks of nasopharyngeal carcinoma and ulcerative colitis.
- The SP score could guide clinical NK cell intervention strategies, including NKG2A blockade therapy.