Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes - PubMed
6 hours ago
- #Drug Resistance
- #Mitochondrial Proteomics
- #Kinetoplast DNA
- Genetic mutation in γATPase subunit leads to kinetoplast DNA (kDNA) loss in Trypanosoma brucei.
- Engineered T. brucei mutants (M282F, M282W, M282Y) show kDNA-independent survival and drug resistance.
- Homozygous M282F mutation causes acriflavine resistance and ATP synthase subunit depletion.
- kDNA loss triggers mitochondrial proteome remodeling, affecting RNA-processing and transporters.
- γATPase mutations are linked to multidrug resistance and geographic spread beyond Africa.